Peer-reviewed research
Effect of Hypothyroidism on the Risk of Carpal Tunnel Syndrome and Electrodiagnostic Parameters
Abuzinadah, Neurology International, 2025
Read the originalRead on October 16, 2026
- What it is
- A retrospective study of 480 patients referred for upper limb nerve testing, comparing carpal tunnel syndrome between people with and without hypothyroidism. It found that the overall association was not significant after adjustment, but that it was significant in patients under 50.
- How much weight it carries
- Peer-reviewed. A single referral clinic with a retrospective design, so it can show associations but not causes. The subgroup under 50 is small, so treat the subgroup result as a signal to test, not a settled finding.
Facts taken from this source
- In the same 2025 study of 480 referred patients, after adjusting for age and sex, the overall association between hypothyroidism and carpal tunnel syndrome was not statistically significant.
“after adjusting for age and gender, logistic regression analysis revealed a non-significant association between hypothyroidism and CTS” (Abstract, Results)
- In a 2025 retrospective study of 480 referred patients, carpal tunnel syndrome was more common among people under 50 with hypothyroidism, with an odds ratio of 2.59.
“CTS was more prevalent among patients with hypothyroidism under 50 years of age (OR: 2.59” (Abstract, Results)