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32patients
A 1993 randomised trial of 32 people with carpal tunnel syndrome found no difference between pyridoxine and placebo in nerve tests, clinical signs or significant symptoms.
Checked against its source on October 16, 2026
In the source's own words
“Thirty-two patients with the disease were randomized to receive treatment or placebo. No differences in outcome were found in electrophysiologic signs, clinical signs, or significant symptoms.”
Effect of pyridoxine on idiopathic carpal tunnel syndrome, GR Spooner et al., Canadian Family Physician, 1993, Abstract.
Open the original- What it measures
- The trial was prospective, and its authors concluded that the findings do not support pyridoxine for this condition.
- What it does not show
- Small trial, so a modest benefit could not be ruled out with certainty.