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10.2percent
In patients having surgery for idiopathic carpal tunnel syndrome, a recent study found amyloidosis on tenosynovial biopsy in 10.2 percent of men over 50 and women over 60, and all of those positive patients had bilateral symptoms.
Checked against its source on October 16, 2026
In the source's own words
“amyloidosis by tenosynovial biopsy in 10.2% of men older than 50 years and women older than 60 years; all positive patients had bilateral symptoms”
Carpal Tunnel Syndrome: A Potential Early, Red-Flag Sign of Amyloidosis, JP Donnelly et al., The Journal of Hand Surgery (American Volume), 2019, Abstract.
Open the original (DOI 10.1016/j.jhsa.2019.06.016)- What it measures
- The figure comes from a study of people having carpal tunnel surgery for idiopathic (no known cause) carpal tunnel syndrome. The review cites it as the reason for renewed interest in amyloid as a cause.
- What it does not show
- It is a surgical population, not the general population, and the review quotes the finding from one earlier study. Do not read it as the chance that any one person with carpal tunnel syndrome has amyloidosis.