Peer-reviewed research
Carpal Tunnel Syndrome in Transthyretin Cardiac Amyloidosis: Implications and Protocol for Diagnosis and Treatment
Ryan P Boyle, Cureus, 2021 · DOI 10.7759/cureus.14546
Read the originalRead on October 16, 2026
- What it is
- A review from Nova Southeastern University that describes transthyretin (TTR) amyloid deposits in the flexor tenosynovium causing carpal tunnel syndrome, and that carpal tunnel syndrome can come years before heart involvement. It presents two patient cases and a diagnostic protocol.
- How much weight it carries
- Peer-reviewed open-access review. The timing claim draws on other reports and case series, not a prospective cohort, and the paper itself presents two cases. Use the five-to-ten-year interval as an approximate figure.
Facts taken from this source
- Carpal tunnel syndrome can develop five to ten years before cardiac amyloidosis, which is why it can serve as an early indicator of the heart condition.
“CTS develops five to ten years prior to cardiac amyloidosis (CA)” (Introduction)