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Carpal tunnel syndrome can be caused by the deposition of misfolded amyloid proteins, and it is often an early sign of systemic amyloidosis.
Checked against its source on October 16, 2026
In the source's own words
“Carpal tunnel syndrome (CTS) can be caused by the deposition and accumulation of misfolded proteins called amyloid and is often an early manifestation of systemic amyloidosis.”
Carpal Tunnel Syndrome: A Potential Early, Red-Flag Sign of Amyloidosis, JP Donnelly et al., The Journal of Hand Surgery (American Volume), 2019, Abstract.
Open the original (DOI 10.1016/j.jhsa.2019.06.016)- What it measures
- A review by cardiologists and a hand surgeon at the Cleveland Clinic. The authors describe amyloid as an early sign that can precede heart and nerve involvement.
- What it does not show
- A review article. Amyloidosis is uncommon, so most people with carpal tunnel syndrome do not have it, and the review does not give a rate in the general population.